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首頁>>免疫學>>一抗>>半乳糖凝集素3抗體
半乳糖凝集素3抗體
  • 產品貨號:
    BN40632R
  • 中文名稱:
    半乳糖凝集素3抗體
  • 英文名稱:
    Rabbit anti-Galectin 3 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規格

    售價

    備注

  • BN40632R-100ul

    100ul

    ¥2360.00

    交叉反應:Human,Mouse(predicted:Rat,Dog) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40632R-200ul

    200ul

    ¥3490.00

    交叉反應:Human,Mouse(predicted:Rat,Dog) 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱Galectin 3
中文名稱半乳糖凝集素3抗體
別    名Galectin-3; 35 kDa lectin; Carbohydrate binding protein 35; CBP 35; CBP35; GAL 3; GAL3; GAL-3; Galactose specific lectin 3; Galactose-specific lectin 3; Galactoside binding protein; Galactoside-binding protein; GALBP; Galectin3 internal gene,included; Galectin-3; Galectin3; GALIG; GBP; IgE binding protein; IgE-binding protein; L 31; L 34; L-34 galactoside-binding lectin; L31; Laminin binding protein; Laminin-binding protein; Lectin galactose binding soluble 3; Lectin galactoside binding soluble 3; Lectin L 29; Lectin L-29; Lectin, galactose binding, soluble 3; LGALS 3; LGALS2; LGALS3; LGALS3 protein; MAC 2 antigen; Mac-2; MAC2; Macrophage galactose-specific lectin; MGC105387;Galectin- 3; LEG3_HUMAN.  





研究領域腫瘤  細胞生物  免疫學  細胞凋亡  細胞粘附分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, Dog, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
細胞定位細胞核 細胞漿 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Galectin 3:181-250/250 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].

Function:
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Subunit:
Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

Subcellular Location:
Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

Tissue Specificity:
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.

Similarity:
Contains 1 galectin domain.

SWISS:
P17931

Gene ID:
3958

Database links:

Entrez Gene: 3958 Human

Entrez Gene: 16854 Mouse

Entrez Gene: 83781 Rat

Omim: 153619 Human

SwissProt: P17931 Human

SwissProt: P16110 Mouse

SwissProt: P08699 Rat

Unigene: 531081 Human

Unigene: 248615 Mouse

Unigene: 764 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Galectin-3是Galectin(半乳凝素)家族的一員,能識別糖蛋白和糖脂的特異性低聚糖結構,參與多種生理和病理過程,包括細胞生長和凋亡、細胞黏附、新生血管形成和腫瘤浸潤與轉移等。Galectin-3在腫瘤的發生、發展及轉移中起重要作用。
Galectin-3在某些腫瘤組織中高表達,其在不同類型腫瘤,如結直腸癌、胃癌、胰腺癌、甲狀腺癌及肺癌等患者中的高表達水平,與低生存、腫瘤復發、預后差及對化療藥物敏感性降低相關對于某些腫瘤,Galectin-3有可能成為一個有價值的診斷標志和治療靶點。